Project summary

Title:

Non-invasive multi-omics biomarkers in immune cells subtypes for personalized medicine in childhood asthma and molecular mechanisms of non-response to inhaled corticosteroids

Principal Investigator:

prof. dr. Uroš Potočnik (Medicinska fakulteta Univerze v Mariboru)

Associated from Medical Faculty, University of Maribor:

asist. dr. Tomaž Budefeld, doc. dr. Helena Sabina Čelešnik, izr. prof. dr. Jernej Dolinšek, dr. Boris Gole, izr. prof. dr. Mario Gorenjak, asist. dr. Larisa Goričan, red. prof. dr. Radovan Hojs, asist. dr. Gregor Jezernik, asist. dr. Staša Jurgec, red. prof. dr. Ivan Krajnc, Martina Krušič, red. prof. dr. Nataša Marčun Varda, dr. Martina Marič, red. prof. dr. Dušica Pahor, dr. Maya Petek, red. prof. dr. Uroš Potočnik

Duration:

2022-2025

Iz vsebine

Summary:

The project is based on a comprehensive analysis of data from various omics, covering genomics (NGS, genotyping), transcriptomics (RNAseq), proteomics, epigenomics (DNA and histone modifications) and regulatory processes (non-coding RNA profiles, splicing variants). Using advanced bioinformatics methods, we will integrate these data and correlate them with clinical outcomes.

 
Role of MF:

Integration of genetic (NGS, genotyping), expression (RNAseq), proteomic, epigenetic (DNA and histone modification) and regulatory (non-coding RNA profiles, splice variants) data with bioinformatics tools (gene ontology - GO) and association to clinical data.